Tag: LSD

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Interaction of LSD with Other Drugs

Basic LSD Information

LSD holds a prominent position as a popular psychedelic due to its extensive historical use and research. Despite its exceptionally high potency, LSD is considered relatively safe. It serves as the archetype for other psychedelics and continues to maintain widespread popularity.

Dosage* Expected Potency
15 – 30 µg Minimal threshold for effect / microdoses
30 – 50 µg Low dose
50 – 100 µg Medium dose
100 – 150 µg Standard dose (1 typical tab)
150 – 300 µg Strong dose
300 µg + Heavy dose

*This chart indicates the oral dosage quantity for pure LSD, measured in micrograms (µg). Micgrograms are 1/1,000,000 of a gram.

LSD Duration


The following duration times apply to all routes of LSD administration:
Onset: 30 – 90 minutes
Duration: 6 – 12 hours
After effects: 12 – 24 hours

Take caution when mixing LSD with the following:

  • Cannabis: The combination of LSD with cannabis produces a remarkably potent and to some extent, unpredictable synergistic effect.
  • Amphetamines and Cocaine: The use of stimulants heightens anxiety levels and escalates the likelihood of thought loops, which can result in unfavorable experiences.

Mixing LSD with the following is considered unsafe:

  • Tramadol: Tramadol is recognized for its ability to lower the threshold for seizures, which means it can increase the chances of a seizure. At the same time, psychedelics (like LSD) have been associated with sporadic instances of seizures.

Mixing LSD with the following is considered low risk** with the potential of increasing the effects of LSD:

  • Mushrooms
  • DMT
  • Mescaline
  • DOx
  • NBOMes
  • 2C-x
  • 2C-T-x
  • αMT
  • 5-MeO-xxT
  • Ketamine
  • MXE
  • DXM
  • PCP
  • N2O
  • MDMA

Mixing the following with LSD are considered low risk with no increased effects of LSD:

  • Caffeine
  • LSD

Mixing the following with LSD are considered low risk with decreased the effects of LSD:

  • Alcohol
  • GHB/GBL
  • Mescaline
  • Benzodiazepines
  • MAOIs
  • SSRIs

**Low risk in this context doesn’t mean that consuming these drugs is safe. It means that the overall risk isn’t increased significantly when they interact with LSD.

The Importance of Testing Drugs You Intend to Mix

You should always test your drugs prior to consumption to decrease the chances of a dangerous side effects or overdose/overamping when substances are misrepresented. This is especially true when mixing drugs, as the dangers are amplified.

Stay safer and get a drug testing kit.

Remember: When it’s suss, Test Kit Plus.

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Is LSD Addictive?

Research on LSD indicates that LSD is not considered to be addictive, nor to cause compulsive use.

What makes LSD so different from highly addictive drugs such as opioids or other stimulants like cocaine?

  1. The intensity of the trip: One reason for LSD to be considered difficult to become addicted to, is the intensity of its effect. The intense and long-lasting experience that comes with using LSD non-medically can be physically and mentally challenging, leading people to limit their frequency of use.
  2. Tolerance: LSD has a quick tolerance build-up, making it difficult to have any effect after more than four days of repeated usage. This is another great reason why it is not recommended to take LSD frequently. Additionally, due to the similar brain receptors involved in their effects, cross-tolerance occurs with psilocybin and LSD, so if someone takes psilocybin mushrooms one day, the effects of taking LSD the next day will be greatly diminished. This is an important point to consider when deciding whether or not to use LSD.

Can you become psychologically dependant on LSD?

While LSD is not considered to be physically addictive, it can have a significant impact on a person’s mental health and lead to the development of a psychological dependence.

Repeated use of LSD can result in the person becoming psychologically dependent on the drug and feeling that they need it in order to cope with the demands of daily life. This can lead to a pattern of continued use, despite negative consequences and a desire to quit.

Why is cocaine addictive and LSD is not?

Cocaine is considered to be addictive because it directly affects the brain’s reward system, increasing the release of dopamine, a neurotransmitter associated with feelings of pleasure and reward. This results in a powerful reinforcement of drug-seeking behaviour and a cycle of continued use, despite negative consequences.

In contrast, LSD does not have the same direct effect on the brain’s reward system, and although it can cause profound changes in thoughts, feelings, and perceptions, it is not considered to be physically addictive in the same way that cocaine and other drugs of abuse are.

How can we reduce the risks associated with using LSD?

  1. Dosage: Keep in mind that LSD is active at very low doses, as little as 20 micrograms (0.0000007 oz), and can have vastly different effects depending on the amount taken and the individual.
  2. Timing: It is also important to note that the effects of LSD may not be noticeable for up to an hour after ingestion, and can gradually increase in intensity over the first two hours. To ensure a pleasant experience, it is best to follow the “start low, go slow” method when using LSD.
  3. Setting: LSD has the potential to evoke conscious awareness of subconscious thoughts and feelings, such as repressed memories, feelings about life circumstances, fantasies, or deep fears. If you choose to use LSD, it is important to be in an environment where you feel safe and with people you trust.
  4. TEST YOUR DRUGS. It is thought that is not possible to fatally overdose with LSD. However, due to the lack of quality control regulations under prohibition, doses are often misrepresented and may contain other drugs (DOB, DOI, NBOMe) that do come with more physical risks, including the potential for fatal overdose.

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Microdosing for Beginners

What is Micro-dosing?

Micro-dosing involves taking a tiny dose of psychedelic hallucinogens or other drugs. Most popularly, people use magic mushrooms (psilocybin) or LSD (acid), but you could potentially micro-dose on any substance. When taking a micro-dose, you should not experience sensory or cognitive distortion. If you do, decrease the dose!

What are the benefits of micro-dosing?

Most data collected indicating potential health benefits of micro-dosing were collected through self-reporting, which is not the most reliable way. However, more and more studies are investigating their direct effect. Another issue, is that we don’t really know the long-term effects of micro-dosing.

A study in Harm Reduction Journal categorized several possible benefits from reports by microdosers. These benefits include:

  1. Improved focus, concentration, and mindfulness
  2. Improved energy, wakefulness, and stimulation
  3. Cognitive benefits, such as enhanced problem solving
  4. Social benefits
  5. Reduced anxiety
  6. Creativity
  7. Reduced symptoms, such as stress
  8. Improved mood, optimism, and life appreciation
  9. Improved body functioning
  10. Self-efficacy, including improved ambition, productivity, and motivation

Microdosing Protocols

There are different protocols that can help guide you through this journey. All of them include a resting period of 2-4 weeks after finishing a cycle of 4-8 weeks of micro-dosing. This is an essential step to avoid building tolerance and maintain the beneficial effects.

  1. Fadiman Protocol
  2. Micro-dosing Institute Protocol
  3. MDI
  4. Stamet’s Protocol
  5. Nightcap Protocol
  6. Intuitive micro-dosing

James Fadiman’s Protocol

The most well-known micro-dosing protocol is named after Dr. James Fadiman. He created this protocol to observe the effects of micro-dosing by clearly distinguishing between micro-dosing days and non-microdosing days.

Cycle:

  • DAY 1: 1st micro-dosing day
  • DAY 2: transition day (after glow effect)
  • DAY 3: normal day
  • DAY 4: 2nd micro-dosing day

CYCLE: Continue this cycle for four to eight weeks
RESET: Two to four weeks of rest

Micro-dosing recommendations:

  • Be conservative when it comes about dosage and days between doses. Dr. Fadiman recommends something like one-tenth of a normal dose. For LSD, a normal dose could be between 100-120 micrograms (mcg), so a micro-dose should be between 6 and 12 mcg. However, you are your own expert, listen to your body!
  • Follow your nomal patters: make sure you eat as normal, drink water, take your medication, have restful sleep, and any normal activity you follow.
  • Be discreet about who you tell about your experience.
  • Test your substance! No benefit will come from a laced substance.

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