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Interaction of LSD with Other Drugs

Last updated on September 12th, 2023

Basic LSD Information

LSD holds a prominent position as a popular psychedelic due to its extensive historical use and research. Despite its exceptionally high potency, LSD is considered relatively safe. It serves as the archetype for other psychedelics and continues to maintain widespread popularity.

Dosage* Expected Potency
15 – 30 µg Minimal threshold for effect / microdoses
30 – 50 µg Low dose
50 – 100 µg Medium dose
100 – 150 µg Standard dose (1 typical tab)
150 – 300 µg Strong dose
300 µg + Heavy dose

*This chart indicates the oral dosage quantity for pure LSD, measured in micrograms (µg). Micgrograms are 1/1,000,000 of a gram.

LSD Duration

The following duration times apply to all routes of LSD administration:
Onset: 30 – 90 minutes
Duration: 6 – 12 hours
After effects: 12 – 24 hours

Take caution when mixing LSD with the following:

  • Cannabis: The combination of LSD with cannabis produces a remarkably potent and to some extent, unpredictable synergistic effect.
  • Amphetamines and Cocaine: The use of stimulants heightens anxiety levels and escalates the likelihood of thought loops, which can result in unfavorable experiences.

Mixing LSD with the following is considered unsafe:

  • Tramadol: Tramadol is recognized for its ability to lower the threshold for seizures, which means it can increase the chances of a seizure. At the same time, psychedelics (like LSD) have been associated with sporadic instances of seizures.

Mixing LSD with the following is considered low risk** with the potential of increasing the effects of LSD:

  • Mushrooms
  • DMT
  • Mescaline
  • DOx
  • NBOMes
  • 2C-x
  • 2C-T-x
  • αMT
  • 5-MeO-xxT
  • Ketamine
  • MXE
  • DXM
  • PCP
  • N2O
  • MDMA

Mixing the following with LSD are considered low risk with no increased effects of LSD:

  • Caffeine
  • LSD

Mixing the following with LSD are considered low risk with decreased the effects of LSD:

  • Alcohol
  • Mescaline
  • Benzodiazepines
  • MAOIs
  • SSRIs

**Low risk in this context doesn’t mean that consuming these drugs is safe. It means that the overall risk isn’t increased significantly when they interact with LSD.

The Importance of Testing Drugs You Intend to Mix

You should always test your drugs prior to consumption to decrease the chances of a dangerous side effects or overdose/overamping when substances are misrepresented. This is especially true when mixing drugs, as the dangers are amplified.

Stay safer and get a drug testing kit.

Remember: When it’s suss, Test Kit Plus.