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Mescaline – A Drug Used for Over 5,000 Years

Last updated on May 5th, 2023

Where does Mescaline come from?

Mescaline is a powerful psychedelic hallucinogen that has been used by people for hundreds of years, primarily in religious rituals or ceremonies. It is found in the small, spineless cactus Peyote (Lophophora williamsi), the San Pedro cactus, Peruvian torch cactus, and other mescaline-containing cacti, as well as certain members of the Fabaceae (bean family).

Mescaline can also be produced synthetically.

Desired Effects of Mescaline

Mescaline’s effect is similar to those of LSD or psilocybin (magic mushrooms), producing intense visual hallucinations.

  • Euphoria
  • Empathy
  • Insight
  • Brightened colors
  • Closed or open eye visuals
  • Enhanced tactile sensation
  • Mental and physical stimulation
  • Decreased appetite
  • Changes in perception
  • Ego softening

Undesired Effects of Mescaline

  • Decreased appetite
  • Pupil dilation
  • Restlessness
  • Sweating and chills
  • Confusion
  • Insomnia
  • Intense nausea and vomiting
  • Increased heart rate and blood pressure
  • Rise in body temperature that causes heavy perspiration, headaches, muscle weakness, and impaired motor coordination

While these drugs can be dangerous and should be used with caution, they can also lead to powerful and meaningful experiences.

How is Mescaline consumed?

The crown of the cactus above ground consists of disc-shaped buttons that are cut from the roots and dried. These buttons can be:

  • Chewed
  • Soaked in water to produce an intoxicating tea
  • Consumed raw or dried
  • Ground into powder for oral capsules
  • Smoked with marijuana and tobacco

San Pedro

The pre-Columbian cultures of Cupisnique (1500 BC), Chavin (1000 BC), Moche (100-750 AD) and Lambayeque (750-1350 AD) all used San Pedro for magical-religious purposes.

This sacred cactus, which contains mescaline, is still used today by master shamans to perform healing rites. During the ritual, known as ‘levantar’ (raise) or ‘mesa’, the shaman sniffs tobacco with alcohol, ingests San Pedro, identifies the diseases, cleanses away evil and helps the patient to ‘florecer’ (flourish).


Peyote has been an integral part of many Indigenous American cultures. For centuries, it has been consumed as part of spiritual rituals and ceremonies.

It wasn’t until 1918 that the Native American Church was officially established in Oklahoma, recognizing the use of Peyote as a sacrament within a Christian religion. This was a major milestone in the history of Peyote and Indigenous American culture, and it is a testament to the perseverance of these communities in preserving their spiritual practices.

Testing for the Presence of Mescaline

Dealers don’t always sell what they say they’re selling. The chances of a dangerous side effects or overdose/overamping is increased when substances are misrepresented.

Stay safer, get a test kit.

We recommend the following kits to test for Mescaline:
Marquis Test »
Froehde Test »